Back to Search
Start Over
Iterative in silico identification of P-glycoprotein inhibitors.
- Source :
- Drug Week; 2024, p447-447, 1p
- Publication Year :
- 2024
-
Abstract
- A recent preprint abstract discusses the development of novel inhibitors for P-glycoprotein (P-gp), a transporter that plays a role in multidrug resistance (MDR) in cancer cells. The researchers used virtual-assisted drug discovery to identify compounds that target the nucleotide binding domains of P-gp, which are underutilized as drug discovery targets. Through an iterative screening process, they identified nine novel P-gp inhibitors that reversed MDR in human cancer cell lines. These inhibitors were chemically diverse, non-toxic to non-cancerous cells, and not transport substrates of P-gp. However, it is important to note that this research has not yet undergone peer review. [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 15316440
- Database :
- Supplemental Index
- Journal :
- Drug Week
- Publication Type :
- Periodical
- Accession number :
- 176184833