New Carboxylic Ester Hydrolases Study Findings Have Been Reported by Researchers at University of North Carolina Chapel Hill (Acute Effects of Monoacylglycerol Lipase Inhibitor Abx1431 On Neuronal Hyperexcitability, Nociception, Locomotion, and...).

Researchers at the University of North Carolina Chapel Hill have conducted a study on the effects of a monoacylglycerol lipase (MAGL) inhibitor called ABX1431 on neuronal hyperexcitability, nociception, locomotion, and the endocannabinoid system in male mice. The study found that ABX1431 reversed Tat-induced neuronal hyperexcitability in vitro and increased overall total distance traveled and speed in mice. Additionally, ABX1431 upregulated 2-arachidonoylglycerol (2-AG) levels in the striatum and spinal cord, indicating potential neuroprotective effects. The research was funded by the NIH National Institute on Drug Abuse and the Japan Society for the Promotion of Science. [Extracted from the article]