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Western outcomes of circumferential endoscopic submucosal dissection for early esophageal squamous cell carcinoma.

Authors :
Rodríguez de Santiago, Enrique
van Tilburg, Laurelle
Deprez, Pierre H.
Pioche, Mathieu
Pouw, Roos E.
Bourke, Michael J.
Seewald, Stefan
Weusten, Bas L.A.M.
Jacques, Jeremie
Leblanc, Sara
Barreiro, Pedro
Lemmers, Arnaud
Parra-Blanco, Adolfo
Küttner-Magalhães, Ricardo
Libânio, Diogo
Messmann, Helmut
Albéniz, Eduardo
Kaminski, Michal F.
Mohammed, Noor
Ramos-Zabala, Felipe
Source :
Gastrointestinal Endoscopy; Apr2024, Vol. 99 Issue 4, p511-511, 1p
Publication Year :
2024

Abstract

Circumferential endoscopic submucosal dissection (cESD) in the esophagus has been reported to be feasible in small Eastern case series. We assessed the outcomes of cESD in the treatment of early esophageal squamous cell carcinoma (ESCC) in Western countries. We conducted an international study at 25 referral centers in Europe and Australia using prospective databases. We included all patients with ESCC treated with cESD before November 2022. Our main outcomes were curative resection according to European guidelines and adverse events. A total of 171 cESDs were performed on 165 patients. En bloc and R0 resections rates were 98.2% (95% confidence interval [CI], 95.0-99.4) and 69.6% (95% CI, 62.3-76.0), respectively. Curative resection was achieved in 49.1% (95% CI, 41.7-56.6) of the lesions. The most common reason for noncurative resection was deep submucosal invasion (21.6%). The risk of stricture requiring 6 or more dilations or additional techniques (incisional therapy/stent) was high (71%), despite the use of prophylactic measures in 93% of the procedures. The rates of intraprocedural perforation, delayed bleeding, and adverse cardiorespiratory events were 4.1%, 0.6%, and 4.7%, respectively. Two patients died (1.2%) of a cESD-related adverse event. Overall and disease-free survival rates at 2 years were 91% and 79%. In Western referral centers, cESD for ESCC is curative in approximately half of the lesions. It can be considered a feasible treatment in selected patients. Our results suggest the need to improve patient selection and to develop more effective therapies to prevent esophageal strictures. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00165107
Volume :
99
Issue :
4
Database :
Supplemental Index
Journal :
Gastrointestinal Endoscopy
Publication Type :
Academic Journal
Accession number :
176099768
Full Text :
https://doi.org/10.1016/j.gie.2023.10.042