New Life Science Findings from Jilin University Described (Ndv Inhibited Ifn-b Secretion Through Impeding Chchd10-mediated Mitochondrial Fusion To Promote Viral Proliferation).

A recent study conducted by researchers at Jilin University in Changchun, China, has investigated the mechanism by which the Newcastle disease virus (NDV) promotes its own replication. The study found that NDV inhibits the fusion of cellular mitochondria, which is associated with interferon-beta (IFN-beta) secretion during NDV infection. Specifically, the downregulation of a mitochondrial protein called CHCHD10 negatively affects the fusion of mitochondria, leading to a decrease in IFN-beta secretion. The researchers concluded that NDV enhances its replication by inhibiting CHCHD10 and suppressing IFN-beta production. This research has been peer-reviewed and published in Veterinary Microbiology. [Extracted from the article]