PI3K-dependant reprogramming of hexokinase isoforms controls glucose metabolism and functional responses of B lymphocytes.

A preprint abstract from biorxiv.org discusses the impact of the PI3K signaling pathway on B cell metabolism and immune functions. The study found that PI3K{delta} signaling can upregulate hexokinase 2 (HK2), an enzyme involved in glucose metabolism. HK2 is selectively expressed during B cell activation and plays a role in glycolysis and ATP production. Deletion of HK2 in mice resulted in impaired B cell development and functional responses, as well as altered metabolic profiles. The study also found that HK2 expression in human chronic lymphocytic leukemia (CLL) cells was associated with recent proliferation and could be reduced by PI3K inhibition. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]