Researchers at National Medical Research Center for Obstetrics Publish New Data on Sertoli-Leydig Cell Tumor (Androgen Insensitivity Syndrome with Bilateral Gonadal Sertoli Cell Lesions, Sertoli-Leydig Cell Tumor, and Paratesticular Leiomyoma:...).

A recent report from the National Medical Research Center for Obstetrics in Moscow, Russia, discusses the rare condition known as Androgen Insensitivity Syndrome (AIS). AIS is caused by mutations in the androgen receptor gene, resulting in individuals with male chromosomes (46,XY) having a female phenotype. The report focuses on a 15-year-old patient with AIS who underwent surgery and was found to have Sertoli cell hamartomas, adenomas, Sertoli-Leydig cell tumors, and a paratesticular leiomyoma. The study also includes a systematic literature review of reported cases of AIS with Sertoli cell lesions/tumors, highlighting the need for further research to understand the prognosis of these tumors in AIS patients. [Extracted from the article]