University College of Medical Sciences & Guru Teg Bahadur Hospital Researchers Describe New Findings in Medical and Health Science (Transcriptional analysis of Metalloprotease, Metallocarboxypeptidase, Isocitrate lyase, Citrate synthase, Malate...).

A recent study conducted by researchers at the University College of Medical Sciences & Guru Teg Bahadur Hospital in Delhi, India, focused on dermatophytes, which are pathogenic fungi that cause cutaneous infections in humans and animals. The study analyzed 160 samples from clinically diagnosed onychomycosis patients and found that Trichophyton rubrum, Trichophyton mentagrophytes, and Microsporum canis secrete metalloproteases, which are enzymes that break down proteins. The researchers also identified other enzymes, such as metallocarboxypeptidase, isocitrate lyase, citrate synthase, malate synthase, and dipeptidylpeptidase V, that are expressed in Trichophyton rubrum isolates from dermatophytosis patients. This research provides valuable insights into the mechanisms of fungal infections and may contribute to the development of new treatments. [Extracted from the article]