New Mesenchymal Stem Cells Data Have Been Reported by Investigators at Fujian Medical University (Overexpression of Runx1 Mitigates Dexamethasone-induced Impairment of Osteogenic Differentiation and Oxidative Stress Injury In Bone Marrow...).

Researchers at Fujian Medical University in Fuzhou, China have conducted a study on the effects of dexamethasone (Dex) on bone marrow mesenchymal stem cells (BMSCs). They found that Dex impaired osteoblast differentiation and caused oxidative stress in BMSCs. The researchers investigated the molecular pathway through which Dex influences osteogenic differentiation and oxidative stress in BMSCs. They discovered that overexpression of the RUNX1 gene mitigated the negative effects of Dex by promoting the transcription of alpha-2 macroglobulin (A2M). This research provides insights into potential strategies for protecting BMSCs from Dex-induced impairment. [Extracted from the article]