BMP signaling to pharyngeal muscle in the C. elegans response to a bacterial pathogen regulates anti-microbial peptide expression and pharyngeal pumping (Updated February 14, 2024).

A recent study investigated the response of the nematode C. elegans to bacterial pathogens and found that the bone morphogenetic protein (BMP) signaling pathway plays a role in this response. The study identified the pharynx as a tissue that responds to BMP signaling and coordinates a systemic response to bacterial pathogens. The researchers also discovered that the expression of certain antimicrobial peptide genes and pharyngeal pumping activity are regulated by BMP signaling. This research provides insights into the host response to pathogens and the role of BMP signaling in infection. However, it is important to note that this study has not yet undergone peer review. [Extracted from the article]