Challenges and Opportunities in Pathogen Agnostic Sequencing for Public Health Surveillance: Lessons Learned From the Global Emerging Infections Surveillance Program.

Pathogen agnostic sequencing, also known as metagenomic sequencing, is a useful tool for biodefense and public health surveillance. It involves sequencing genetic material in a sample to detect and monitor infectious diseases. Next-generation sequencing technologies have made this method more affordable and accessible. The US Department of Defense's Global Emerging Infections Surveillance program has successfully integrated pathogen agnostic sequencing into its infectious disease surveillance network. The program has established a consortium to promote collaboration and standardization, conducted proficiency testing exercises, and funded surveillance activities using this method. The text discusses the challenges and opportunities associated with pathogen agnostic sequencing, highlighting the need for standardized protocols and methods, as well as collaboration between the biodefense and public health communities. The conclusion emphasizes the value of past investments in this technology and the need for continued investment to prepare for future threats. [Extracted from the article]