COVID-19 Treated with Minocycline and Saiko-keishi-to: A Case Report.

Introduction: Since the beginning of 2020, tetracycline, such as minocycline (MIN), has been used to inhibit coronavirus disease 2019 (COVID-19). Traditional Japanese Kampo medicine, such as Saiko-keishi-to (SKT), has recently received a lot of attention for its anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) effects. We describe a COVID-19 patient treated with MIN and SKT. Case Report: A 90-year-old male patient was referred to a medical clinic due to fever, appetite loss, and general malaise. Based on positive SARS-CoV-2 rapid antigen tests, he was diagnosed with COVID-19. He had difficulty in eating on his own. Therefore, he was referred to a hospital for admission. After admission, he was treated with molnupiravir to avoid aggravation. Seven days after his admission, he was discharged. After his discharge, he was referred to our hospital due to prolonged fever and general malaise. As a precaution, a real-time reverse transcription-polymerase chain reaction (RT-PCR) test was performed, which yielded a positive result. Therefore, the aforementioned symptoms were thought to be caused by prolonged COVID-19. He was treated with MIN and SKT due to the anti-viral properties of these two drugs. As a result, the RT-PCR test became negative, and the fever and general malaise subsided. Conclusion: This case shows treatment with MIN and SKT may be effective in some cases of COVID-19. [ABSTRACT FROM AUTHOR]