Visualizing sarcomere and cellular dynamics in skeletal muscle to improve cell therapies.

A preprint abstract from biorxiv.org discusses the integration of the protein titin into the sarcomere, a structure in skeletal muscle. The study found that titin's integration is tightly regulated and its unexpected mobility helps distribute it evenly after cell fusion, which is important for the formation and maturation of skeletal muscle. In adult mice, the study also showed how myocytes integrate, fuse, and contribute to the continuous myofilament system across cell boundaries. The findings have implications for future cell-based therapies for skeletal muscle disease. However, it's important to note that this preprint has not been peer-reviewed. [Extracted from the article]