Data on Life Science Discussed by Researchers at University of Ljubljana (Benzothiazole Dna Gyrase Inhibitors and Their Conjugates With Siderophore Mimics: Design, Synthesis and Evaluation).

Researchers at the University of Ljubljana in Slovenia have conducted a study on benzothiazole-based bacterial DNA gyrase and topoisomerase IV inhibitors as potential antibacterial agents. The aim of the study was to improve the uptake of these inhibitors into the cytoplasm of Gram-negative bacteria by conjugating them to small siderophore mimics. The researchers found that one particular conjugate, 18b, displayed potent inhibition of Escherichia coli DNA gyrase and topoisomerase IV, and showed enhanced antibacterial activity against E. coli in an iron-depleted medium. This research suggests that the conjugate with a siderophore mimic moiety could be a promising antibacterial agent. [Extracted from the article]