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Bronchodilator Efficacy of High-Flow Nasal Cannula in COPD: Vibrating Mesh Nebulizer Versus Jet Nebulizer.
- Source :
- Respiratory Care; Feb2024, Vol. 69 Issue 2, p157-165, 9p
- Publication Year :
- 2024
-
Abstract
- BACKGROUND: Jet nebulizers are commonly used for bronchodilator therapy in COPD. High-flow nasal cannula with vibrating mesh nebulizer (HFNC-VMN) is a recently developed system; however, few studies have compared the efficacy of bronchodilator administration via HFNC-VMN to jet nebulizer in stable COPD. This study aimed to compare the effect of salbutamol administered via HFNC-VMN versus jet nebulizer on airway and lung function in subjects with stable COPD. METHODS: This randomized non-inferiority crossover physiologic study enrolled subjects with stable COPD. Salbutamol was nebulized via HFNC-VMN or jet nebulizer in random order with a 4-h washout period between crossover sequences. Spirometry, lung volume, and impulse oscillometry were performed at baseline and after each intervention. The primary outcome was change in FEV1 from baseline. Secondary outcomes included changes in other respiratory-related parameters and nebulization time compared between the 2 devices. RESULTS: Seventeen subjects were enrolled. HFNC-VMN and jet nebulizer both significantly improved FEV1 from baseline (P = .005 and P = .002, respectively). The difference between respiratory resistance at 5 Hz and 20 Hz significantly decreased after HFNC-VMN compared to baseline (P = .02), while no significant change was observed after jet nebulizer (P = .056). Area of reactance and resonant frequency of reactance were both significantly decreased (P = .035 and P = .03, respectively), and respiratory reactance at 5 Hz significantly increased (P = .02) in the HFNC-VMN group compared to baseline indicating improved lung mechanics, with no significant changes with the jet nebulizer. HFNC-VMN had a shorter nebulization time (6 [5-9] min vs 20 [16-22] min, respectively, P < .001). CONCLUSIONS: Bronchodilator therapy via HFNC-VMN was not inferior to jet nebulizer for subjects with stable COPD and can significantly improve airway oscillometry mechanics and decrease nebulization time compared to jet nebulizer. [ABSTRACT FROM AUTHOR]
- Subjects :
- STATISTICS
NASAL cannula
CLINICAL trials
ALBUTEROL
LUNGS
MANN Whitney U Test
CONTINUING education units
TREATMENT effectiveness
NEBULIZERS & vaporizers
ARTIFICIAL respiration
RANDOMIZED controlled trials
COMPARATIVE studies
OBSTRUCTIVE lung diseases
HIGH-frequency ventilation (Therapy)
DESCRIPTIVE statistics
RESEARCH funding
CROSSOVER trials
SPIROMETRY
STATISTICAL sampling
DATA analysis software
DATA analysis
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 00201324
- Volume :
- 69
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Respiratory Care
- Publication Type :
- Academic Journal
- Accession number :
- 174985101
- Full Text :
- https://doi.org/10.4187/respcare.11139