Back to Search
Start Over
Scallop hydrolysates/κ-carrageenan hydrogels improve the alleviating effect of curcumin on DSS-induced colitis.
- Source :
- Journal of Functional Foods; Jan2024, Vol. 112, pN.PAG-N.PAG, 1p
- Publication Year :
- 2024
-
Abstract
- [Display omitted] • SK hydrogel as vehicle for Cur delivery to colon exerts potential therapeutic effect. • SK-Cur relieves clinical symptoms in DSS-induced UC mice more effectively than Cur. • SK-Cur ameliorates colitis by regulating oxidative stress and inflammatory responses. • SK-Cur modulates the gut flora community of mice being similar to normal state. Scallop (Patinopecten yessoensis) male gonad hydrolysates/ κ -carrageenan (SK) double cross-linking network hydrogels were constructed as curcumin (Cur) delivery vehicles with good gel mechanical property and homogeneous honeycomb microstructures. Compared with Cur + DSS group, weight loss and colon length in SK-Cur + DSS group increased about 1.04 and 1.06 folds, while the disease active index (DAI) scores decreased about 13 %. Moreover, SK-Cur showed superior effect on intestinal barrier improvement, oxidative stress modulation, and inflammatory expression regulation, reflected by 1.1 folds increment of epithelial tight junction proteins, 16 % and 27 % decline in MPO and iNOS levels, 20 % decline in NF-κB expression, 4 %, 7 %, 6 % decline in TNF-α, IL-1β, IL-6 expression in serum, and 9 %, 20 %, 7 % decline in TNF-α, IL-1β, IL-6 expression in colon tissue. Furthermore, SK-Cur enriched alpha diversity and restored taxonomic composition with increasing Bacteroides and Verrucomicrobia abundance accompanied by decreasing Firmicutes in DSS-induced UC mice, roughly to a normal gut flora state. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17564646
- Volume :
- 112
- Database :
- Supplemental Index
- Journal :
- Journal of Functional Foods
- Publication Type :
- Academic Journal
- Accession number :
- 174789796
- Full Text :
- https://doi.org/10.1016/j.jff.2024.106000