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Chokeberry reduces inflammation in human preadipocytes.
- Source :
- Journal of Functional Foods; Jan2024, Vol. 112, pN.PAG-N.PAG, 1p
- Publication Year :
- 2024
-
Abstract
- [Display omitted] • Chokeberry (Aronia) increases methylation at CpG site in Interleukin-6 promoter. • Chokeberry alleviates inflammation caused by palmitic acid in human preadipocytes. • Aronia reduces inflammation caused by lipopolysaccharides in human preadipocytes. Chokeberry, Aronia melanocarpa , is an indigenous fruit from North America used as food and to prevent chronic disease by Indigenous Peoples. The objective of this study was to test anti-inflammatory effects of anthocyanin on palmitic acid (PA)-induced IL-6 gene expression, IL-6 DNA methylation, and histone (H3) acetylation. Additionally, we examined effects of anthocyanins Cyanidin-3-O-galactoside (C3Gal) and Cyanidin-3-glucoside (C3G) on IL-6 gene expression. Human primary pre-adipocytes were treated with chokeberry juice extract (CBE), C3Gal or C3G in the presence or absence of PA or lipopolysaccharide (LPS). CBE inhibited LPS- and PA-induced IL-6 mRNA expression (p < 0.0001), while C3G and C3Gal had smaller effects. Human IL-6 promoter DNA methylation was increased (p = 0.0256) in CBE treated cells compared to control. Histone H3 acetylations were not affected by CBE or PA treatment. These data indicate that CBE epigenetically reduced PA-induced inflammation by regulating IL-6 DNA methylation without affecting histone modifications in human preadipocyte cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17564646
- Volume :
- 112
- Database :
- Supplemental Index
- Journal :
- Journal of Functional Foods
- Publication Type :
- Academic Journal
- Accession number :
- 174789751
- Full Text :
- https://doi.org/10.1016/j.jff.2023.105947