Investigators at University of Sydney Report Findings in Cancer (Differential Transmetallation of Complexes of the Anti-cancer Thiosemicarbazone, Dp4e4mt: Effects On Anti-proliferative Efficacy, Redox Activity, Oxy-myoglobin and Oxy-hemoglobin...).

Researchers at the University of Sydney in Australia have conducted a study on the anti-cancer properties of a compound called di-2-pyridylthiosemicarbazone (DpT). They synthesized and characterized various complexes of DpT with different metals, including Fe, Co, Ni, Cu, Zn, Ga, and Pd. The study found that the complexes displayed distinct biological activity, with some showing potent anti-proliferative effects against cancer cells. The researchers also observed differences in transmetallation, or the exchange of metals, between the complexes, which affected their efficacy and off-target effects. This research provides valuable insights into the mechanism of action and potential therapeutic applications of these DpT complexes as anti-cancer agents. [Extracted from the article]