North Sichuan Medical College Researcher Releases New Study Findings on Alzheimer Disease (Alpha 2-Macroglobulin Polymorphisms and Susceptibility to Alzheimer's Disease: A Comprehensive Meta-Analysis Based on 62 Studies).

A new meta-analysis conducted by a researcher at North Sichuan Medical College in China explores the relationship between the alpha 2-macroglobulin (A2M) gene and Alzheimer's disease (AD). The study analyzed data from 62 studies and found that the G allele of rs226380 reduced the risk of AD, while the TT genotype increased the risk in Asian populations. Additionally, the V allele of the A2M-I/V (rs669) increased susceptibility to AD in females, but the II genotype was found to be protective. The study suggests that A2M single nucleotide polymorphisms may be associated with AD risk in certain sub-populations, but further research with larger sample sizes is needed to confirm these findings. [Extracted from the article]