Researcher at Radboud University Medical Center Discusses Research in Cerebral Amyloid Angiopathy (Shotgun proteomics for the discovery of protein biomarkers for cerebral amyloid angiopathy).

A study conducted at Radboud University Medical Center focused on the search for protein biomarkers for cerebral amyloid angiopathy (CAA). The researchers used shotgun proteomics analyses to identify potential biomarkers in the cerebrospinal fluid (CSF) of rodent models for CAA. They compared the expression of proteins in these models with wild-type controls and attempted to validate the candidates by analyzing CSF samples from human CAA patients. The study found differential expression levels for cathepsins B and S, as well as hexosaminidase B, in rodents. However, the validation efforts in human biomarker studies did not directly correspond to the biomarker candidates identified from the protein screenings. The study suggests that increased hexosaminidase B expression levels in rodents may be reflected in decreased hexosaminidase activity in human CAA, but further validation is needed. The research was funded by the NIH CAFE project. [Extracted from the article]