New Data from Sapienza University of Rome Illuminate Research in Parkinson's Disease (Exploring the Central Mechanisms of Botulinum Toxin in Parkinson's Disease: A Systematic Review from Animal Models to Human Evidence).

A new report discusses research on the use of botulinum toxin (BoNT) in the treatment of Parkinson's disease (PD). The report highlights that BoNT is an effective and safe therapy for neurological disturbances and provides evidence of its mechanisms of action in the central nervous system. Animal models of PD have shown that intrastriatal administration of BoNT improves motor and non-motor symptoms without neuronal loss. However, there is limited data on the central effects of BoNT in human subjects with PD, and further studies are needed to clarify its potential benefits. [Extracted from the article]