New Cardiac Stressing Agents Study Findings Have Been Reported by Researchers at Daegu University [Sodium-potassium Adenosine Triphosphatase A2 Subunit (Atp1a2) Negatively Regulates Ucp1-dependent and Ucp1-independent Thermogenesis In 3t3-l1...].

Researchers at Daegu University in South Korea have published a new study on the role of sodium-potassium adenosine triphosphatase & alpha;2 subunit (ATP1A2) in adipocytes biology. The study found that suppressing ATP1A2 induced browning in white adipocytes, promoting the expression of brown adipocyte-specific proteins and genes, suppressing adipogenesis and lipogenesis, and enhancing lipolysis and fat oxidation. The deficiency of ATP1A2 also enhanced the expression of marker proteins for both UCP1-dependent and UCP1-independent thermogenesis. The researchers concluded that downregulating ATP1A2 and activating thermogenesis in adipocytes could be a novel approach to treat obesity. [Extracted from the article]