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PSMA PET/CT for Response Assessment of 177Lu-PSMA Therapy.

Authors :
Hartrampf, Philipp E.
Serfling, Sebastian E.
Michalski, Kerstin
Buck, Andreas K.
Werner, Rudolf A.
Source :
Seminars in Nuclear Medicine; Jan2024, Vol. 54 Issue 1, p69-76, 8p
Publication Year :
2024

Abstract

Prostate-specific membrane antigen (PSMA) PET/CT has been widely integrated into the management of prostate cancer (PCa) patients with biochemical recurrence, is increasingly used for initial staging in high-risk patients prior to surgery or to identify candidates for PSMA-targeted radioligand therapy (RLT). To date, monitoring response in PCa patients in prospective studies remains the domain of conventional imaging, such as magnetic resonance/CT or bone scintigraphy. With the increasing use of PSMA-targeted PET/CT in PCa, however, varying criteria based on molecular imaging have been established to define progressive disease, including "PSMA PET Progression Criteria," "Response evaluation criteria in PSMA PET/CT (RECIP 1.0)" or consensus statements of respective societies. In the present review, we will discuss the current status of PSMA PET/CT for response monitoring, focusing on PSMA RLT with [<superscript>177</superscript>Lu]Lu-labeled PSMA ligands, along with a head-to-head comparison of recently published response criteria. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00012998
Volume :
54
Issue :
1
Database :
Supplemental Index
Journal :
Seminars in Nuclear Medicine
Publication Type :
Academic Journal
Accession number :
174033586
Full Text :
https://doi.org/10.1053/j.semnuclmed.2023.06.003