New Mullerian Adenosarcoma Study Findings Have Been Published by Researchers at Institute of Oncology (Clear Cell Carcinoma Arising in Low-Grade Mullerian Adenosarcoma: First Reported Case with Insight into Molecular Profile).

A new report discusses research findings on mullerian adenosarcoma, a rare type of cancer. The report highlights a case study of a patient with a composite tumor consisting of adenosarcoma and clear cell carcinoma (CCC). The study used next-generation sequencing to analyze the genomic profile of both tumor components and found several identical somatic variants, suggesting a common origin. The researchers identified dual amplification of CDK4 and MDM2 as the primary cause of tumor formation, as well as a driver variant in the DHX15 gene. The patient is currently alive without signs of disease recurrence 18 months after surgery. [Extracted from the article]