Accurate OCT-based diffuse adult-type glioma WHO grade 4 tissue classification using comprehensible texture feature analysis.

Maximum safe resection of diffuse adult-type glioma WHO grade 4 (glioma °4) is a well-established procedure in order to prolong a patient's lifetime. However, differentiation between glioma and healthy brain tissue remains a challenge in an intraoperative setting. As shown previously, the attenuation coefficient extracted from OCT images does not provide sufficient discrimination between healthy gray matter and tumor infiltrated tissue. On the other hand, the majority of published approaches based on structural information in OCT images uses sophisticated machine learning approaches as e.g. deep convolutional neural networks which bring the need for large data sets for reasonable modeling. In this work, we propose a method, which is based on comprehensible texture features and provides reasonable classification performance for healthy gray and white matter against glioma °4 samples, while requiring a relatively low number of samples for training. Our sample collective consists of 36 tissue samples from 27 different patients. Texture features based on the average contrast were optimized with respect to best discrimination of the tissue types of interest. Best discrimination could be obtained for the contrast of structure sizes of approximately 100 μ m. By using a linear discriminant analysis (LDA), we could achieve a sensitivity and specificity of 97.7 % and 91.7 % , respectively, when classifying white matter and samples with a mixture of white and gray matter against glioma °4 samples. For an extended data set, also including pure gray matter samples, we determined a sensitivity of 86.7 % and a specificity of 86.3 %. [Display omitted] • Optimized, contrast based texture features enable classification by LDA. • Best discrimination for structure dimensions of approximately 100 µm. • Robust classification by simple features and high accuracy for little training data. • Differentiation of healthy gray and white matter against tumorous tissue. [ABSTRACT FROM AUTHOR]