Studies from University of Buenos Aires Describe New Findings in Porphyromonas gingivalis (Extracellular Vesicles of Porphyromonas gingivalis Disrupt Trophoblast Cell Interaction with Vascular and Immune Cells in an In Vitro Model of...).

A study conducted by researchers at the University of Buenos Aires in Argentina has found that extracellular vesicles released by the bacteria Porphyromonas gingivalis (Pg) disrupt the interaction between trophoblast cells and vascular and immune cells in an in vitro model of early placentation. These vesicles, known as outer membrane vesicles (OMVs), have been associated with the development of systemic diseases such as cardiovascular disease, rheumatoid arthritis, and Alzheimer's disease. The researchers hypothesized that Pg OMVs affect trophoblast cell phenotype, impairing their interactions with endothelial and immune cells. The study suggests that Pg OMVs play a pathogenic role in early stages of pregnancy and placentation by disrupting trophoblast contribution to vascular transformation and immune homeostasis maintenance. [Extracted from the article]