Reports Outline Serratia marcescens Research from Zagazig University (Relocating Glyceryl Trinitrate as an Anti-Virulence Agent against Pseudomonas aeruginosa and Serratia marcescens : Insights from Molecular and In Vivo...).

A report from Zagazig University in Egypt discusses research on Serratia marcescens, a bacterium that causes infections. The study focuses on finding alternative approaches to combat antibiotic resistance, such as disrupting quorum sensing (QS) and inhibiting virulence. The researchers found that glyceryl trinitrate (GTN) at a sub-inhibitory concentration could significantly decrease the expression of virulence genes in Serratia marcescens and Pseudomonas aeruginosa. Additionally, GTN was shown to alleviate congestion in the liver and kidney tissues of infected mice and reduce bacterial and leukocyte infiltration. The study suggests that topical GTN could be used in combination with antibiotics to treat topical infections caused by these bacteria. [Extracted from the article]