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Elucidation of the α‑Ketoamide Inhibition Mechanism: Revealing the Critical Role of the Electrostatic Reorganization Effect of Asp17 in the Active Site of the 20S Proteasome.

Authors :
Zhou, Jiao
Sang, Xiaohong
Wang, Juan
Xu, Yan
An, Jing
Chu, Zhen Tao
Saha, Arjun
Warshel, Arieh
Huang, Ziwei
Source :
ACS Catalysis; 11/3/2023, Vol. 13 Issue 21, p14368-14376, 9p
Publication Year :
2023

Details

Language :
English
ISSN :
21555435
Volume :
13
Issue :
21
Database :
Supplemental Index
Journal :
ACS Catalysis
Publication Type :
Academic Journal
Accession number :
173457758
Full Text :
https://doi.org/10.1021/acscatal.3c03538