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OnabotulinumtoxinA improves oral aperture in patients with scleroderma: A small clinical trial.

Authors :
Gonzalez, Cristian D.
Pamatmat, Jarod John
Burningham, Kevin M.
Yang, Michelle
Goff, Heather W.
Source :
Journal of the American Academy of Dermatology; Nov2023, Vol. 89 Issue 5, p952-958, 7p
Publication Year :
2023

Abstract

Reduced oral aperture (ROA), resulting from systemic sclerosis (SSc), is a debilitating condition with limited treatment options. Improvement in oral function has been reported with perioral administration of botulinum toxin type A. To prospectively evaluate the efficacy of onabotulinumtoxinA (onabotA) injection in improving oral opening and quality of life in SSc patients with ROA. Seventeen women with SSc and ROA were treated with 16 units of onabotA in 8 different sites around the cutaneous lips. Measurements of maximum mouth opening were taken before treatment, at 2 weeks posttreatment, and at 3 months posttreatment. Function and quality of life were also assessed via surveys. Interincisor and interlabial distances were significantly increased 2 weeks after treatment with onabotA (P <.001) but not 3 months after. Subjective improvement in quality of life was noted. This single-institution study enrolled 17 patients and did not have a placebo control group. OnabotA appears to have a strong short-term symptomatic benefit in patients with ROA due to SSc, with possible benefit to quality of life. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01909622
Volume :
89
Issue :
5
Database :
Supplemental Index
Journal :
Journal of the American Academy of Dermatology
Publication Type :
Academic Journal
Accession number :
172890506
Full Text :
https://doi.org/10.1016/j.jaad.2023.04.069