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A nested case-control study of factors contributing to the development of medicationrelated osteonecrosis of the jaw in patients using bone resorption inhibitors in Mishima City.
- Source :
- Journal of Oral Science; 2023, Vol. 65 Issue 3, p184-189, 6p
- Publication Year :
- 2023
-
Abstract
- Purpose: Medication-related osteonecrosis of the jaw (MRONJ) is characterized by necrosis of the jawbone with intraoral bacterial infection and has a significant negative impact on oral health-related quality of life. Risk factors for the onset are unknown, and definitive therapeutic approaches have not yet been defined. A case-control study at a single institution in Mishima City was conducted. The purpose of this study was to examine in detail the factors that contribute to the development of MRONJ. Methods: Medical records of MRONJ patients who visited Mishima Dental Center, Nihon University School of Dentistry, during the period 2015-2021 were extracted. Counter-matched sampling design was used to select participants matched for sex, age, and smoking for this nested casecontrol study. The incidence factors were statistically examined by logistic regression analysis. Results: Twelve MRONJ patients were used as cases and 32 controls were matched. After adjustment for potential confounders, injectable bisphosphonates (aOR = 24.5; 95% CI = 1.05, 575.0; P < 0.05) were significantly associated with the development of MRONJ. Conclusion: High-dose bisphosphonates may be a risk factor for the development of MRONJ. Patients who use these products require careful prophylactic dental treatment against inflammatory diseases, and dentists and physicians should maintain close communication. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13434934
- Volume :
- 65
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Journal of Oral Science
- Publication Type :
- Academic Journal
- Accession number :
- 171980632
- Full Text :
- https://doi.org/10.2334/josnusd.23-0096