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Chapter Two - Regulation of gasdermins in pyroptosis and cytokine release.
- Source :
- Advances in Immunology; 2023, Vol. 158, p75-106, 32p
- Publication Year :
- 2023
-
Abstract
- Gasdermins are effectors of pyroptosis downstream of diverse signaling pathways. Emerging evidence suggests that a number of post-translational modifications regulate the function of gasdermins in pyroptosis, a highly inflammatory form of cell death, and lytic or non-lytic secretion of intracellular contents. These include processing by different caspases and other proteases that may activate or suppress pyroptosis, ubiquitination by a bacterial E3 ligase that suppresses pyroptosis as an immune evasion mechanism, modifications at Cys residues in mammalian or microbial gasdermins that promote or inhibit pyroptosis, and potential phosphorylation that represses pyroptosis. Such diverse regulatory mechanisms by host and microbial proteases, ubiquitin ligases, acyltransferases, kinases and phosphatases may underlie the divergent physiological and pathological functions of gasdermins, and furnish opportunities for therapeutic targeting of gasdermins in infectious diseases and inflammatory disorders. [ABSTRACT FROM AUTHOR]
- Subjects :
- PYROPTOSIS
UBIQUITIN ligases
POST-translational modification
CELL death
CYTOKINES
Subjects
Details
- Language :
- English
- ISSN :
- 00652776
- Volume :
- 158
- Database :
- Supplemental Index
- Journal :
- Advances in Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 169957906
- Full Text :
- https://doi.org/10.1016/bs.ai.2023.03.002