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A physiologically based pharmacokinetic model of cefepime to predict its pharmacokinetics in healthy, pediatric and disease populations.

Authors :
Talha Zahid, Muhammad
Zamir, Ammara
Majeed, Abdul
Imran, Imran
Alsanea, Sary
Ahmad, Tanveer
Alqahtani, Faleh
Fawad Rasool, Muhammad
Source :
Saudi Pharmaceutical Journal; Aug2023, Vol. 31 Issue 8, pN.PAG-N.PAG, 1p
Publication Year :
2023

Abstract

The physiologically based pharmacokinetic modeling (PBPK) approach can predict drug pharmacokinetics (PK) by combining changes in blood flow and pathophysiological alterations for developing drug-disease models. Cefepime hydrochloride is a parenteral cephalosporin that is used to treat pneumonia, sepsis, and febrile neutropenia, among other things. The current study sought to identify the factors that impact cefepime pharmacokinetics (PK) following dosing in healthy, diseased (CKD and obese), and pediatric populations. For model construction and simulation, the modeling tool PK-SIM was utilized. Estimating cefepime PK following intravenous (IV) application in healthy subjects served as the primary step in the model-building procedure. The prediction of cefepime PK in chronic kidney disease (CKD) and obese populations were performed after the integration of the relevant pathophysiological changes. Visual predictive checks and a comparison of the observed and predicted values of the PK parameters were used to verify the developed model. The results of the PK parameters were consistent with the reported clinical data in healthy subjects. The developed PBPK model successfully predicted cefepime PK as observed from the ratio of the observed and predicted PK parameters as they were within a two-fold error range. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13190164
Volume :
31
Issue :
8
Database :
Supplemental Index
Journal :
Saudi Pharmaceutical Journal
Publication Type :
Academic Journal
Accession number :
169752484
Full Text :
https://doi.org/10.1016/j.jsps.2023.06.008