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Discovery of a Novel Bifunctional Steroid Analog, YXG-158, as an Androgen Receptor Degrader and CYP17A1 Inhibitor for the Treatment of Enzalutamide-Resistant Prostate Cancer.

Authors :
Wang, Ao
Luo, Xianggang
Meng, Xin
Lu, Zhengyu
Chen, Kaixian
Yang, Yushe
Source :
Journal of Medicinal Chemistry; 7/27/2023, Vol. 66 Issue 14, p9972-9991, 20p
Publication Year :
2023

Details

Language :
English
ISSN :
00222623
Volume :
66
Issue :
14
Database :
Supplemental Index
Journal :
Journal of Medicinal Chemistry
Publication Type :
Academic Journal
Accession number :
168583466
Full Text :
https://doi.org/10.1021/acs.jmedchem.3c00880