Studies advance knowledge in HIV/AIDS pathogenesis research.

The article presents information on various HIV/AIDS pathogenesis research. A study by H.M. Mo and coworkers, reprted that conserved residues in the HIV-1 gp41 coiled-coil pocket are essential for viral replication. The human immunodeficiency virus type 1 (HIV-1) gp41 plays an important role in mediating the fusion of HIV with host cells. During the fusion process, three N-terminal helices and three C-terminal helices pack in an anti-parallel direction to form a six-helix bundle. Mo and colleagues published their study in the periodical "Virology."