EP039 RETROSPECTIVE REAL WORLD COMPARATIVE EFFECTIVENESS OF OVINE FORESTOMACH MATRIX* AND COLLAGEN/OXIDIZED REGENERATED CELLULOSE^ IN THE MANAGEMENT OF DIABETIC FOOT ULCERS.

Aim: The purpose of this large, retrospective, pragmatic real-world evidence (RWE) study was to directly compare the healing outcomes of diabetic foot ulcers (DFU) treated with either ovine forestomach matrix (OFM) or collagen/oxidized regenerated cellulose (collagen/ORC). Method: The two cohorts consisted of DFU treated with OFM (n=1150) and collagen/ORC (n=1072). Data was extracted from a wound database from 2014 to 2020, representing 449 wound care centers across the United States. Data was extracted from a pool of 31,883 wounds and filtered based on the inclusion and exclusion criteria. The median time to wound closure and the percentage of wounds closed standard intervals were estimated using the Kaplan-Meier method. The percentage of DFUs closed were statistically compared between treatment groups using Greenwood's standard error estimates. Results / Discussion: A sub-analysis was performed to understand the relative efficacy in DFUs requiring longer periods of treatment and showed that OFM-treated DFUs healed up to ~5 weeks faster in this subgroup of more challenging wounds. The percentage of wounds closed at 12-, 24- and 36-weeks was improved in OFM-treated DFUs relative to the collagen/ORC cohort. Conclusion: The results of this large RWE study support the clinical efficacy of OFM in the treatment of challenging DFUs. Further, real-world data studies should be considered an impactful study design in wound healing as RWE studies can more accurately reflect the actual patient population suffering from complex wounds compared to randomized controlled trials. [ABSTRACT FROM AUTHOR]