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Discovery of a Pan-Melanocortin Receptor Antagonist [Ac-DPhe(pI)-Arg-Nal(2′)-Orn-NH2] at the MC1R, MC3R, MC4R, and MC5R that Mediates an Increased Feeding Response in Mice and a 40-Fold Selective MC1R Antagonist...

Authors :
Ericson, Mark D.
Tran, Linh T.
Mathre, Sarah S.
Freeman, Katie T.
Holdaway, Kelsey
John, Kristen
Lunzer, Mary M.
Bouchard, Jacob L.
Haskell-Luevano, Carrie
Source :
Journal of Medicinal Chemistry; 6/22/2023, Vol. 66 Issue 12, p8103-8117, 15p
Publication Year :
2023

Details

Language :
English
ISSN :
00222623
Volume :
66
Issue :
12
Database :
Supplemental Index
Journal :
Journal of Medicinal Chemistry
Publication Type :
Academic Journal
Accession number :
164485688
Full Text :
https://doi.org/10.1021/acs.jmedchem.3c00432