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The change of anti-inflammatory activity in Cinnamomum camphora seed extracts undergo simulated gastrointestinal digestion and alkaline hydrolysis.
- Source :
- Food Bioscience; Jun2023, Vol. 53, pN.PAG-N.PAG, 1p
- Publication Year :
- 2023
-
Abstract
- There were no reports on the anti-inflammatory effect of the seed of C. camphora (CCS) and the changes in the process of processing and consumption. The aim of the study was to investigate the anti-inflammatory activity of CCS ethanol extracts (EE), and the changes of it after simulated gastrointestinal digestion and alkaline hydrolysis in a lipopolysaccharide (LPS)-induced inflammatory macrophages model in vitro. The phytochemical characteristics of EE, digested ethanol extracts (dEE) and hydrolysed ethanol extracts (hEE) were analyzed using UPLC-LTQ-Orbitrap-MS/MS in this study, and 17 chemicals were tentatively identified from the three prepared samples. EE, dEE and hEE may have cell protection function, and both of them exhibited strong anti-inflammatory activity as significantly reduced multiple pro-inflammatory mediators and cytokines secretion and expression. Although the anti-inflammatory activity of EE was decreased by digestion and hydrolysis, and hydrolysis had more negative effect than digestion, most of its anti-inflammatory activity was retained. The mitigation of inflammation of EE may be by suppressing phosphorylation levels of signaling molecules of nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs) signaling pathways. The results suggest that the anti-inflammatory activity of EE is relatively stable undergo gastrointestinal digestion and alkaline hydrolysis, which may facilitate the processing and consumption of related products. [Display omitted] • Ethanol extracts of C. camphora seed exhibited anti-inflammatory activity. • Ethanol extracts may have the function of cell protection. • Hydrolysis and digestion reduced anti-inflammatory activity of ethanol extracts. • Ethanol extracts may mitigate inflammation through NF-κB/MAPK signaling pathways. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 22124292
- Volume :
- 53
- Database :
- Supplemental Index
- Journal :
- Food Bioscience
- Publication Type :
- Academic Journal
- Accession number :
- 164416516
- Full Text :
- https://doi.org/10.1016/j.fbio.2023.102765