Clinical radiation dose verification by topographic persistent luminescence dosimetry.

Radiation dose verification in radiotherapy is essential to determine the dose delivered to irradiated tissue while minimizing normal tissue toxicity. However, the challenge remains in determining topographic radiation dose profiles due to limitations in conventional dosimeters. Herein, we report a robust technique for visualizing and verifying clinical doses based on reusable, flexible scintillating films comprising lanthanide-doped persistent luminescent nanoparticles. These nanoparticle-based films outperform commercially available radiochromic films in terms of linear response to irradiation doses between 0 and 25 Gy. We demonstrate topographic persistent luminescence dosimetry for radiotherapy of mice and rabbits with malignant tumors. Our data show a higher signal-to-background ratio, especially at lower (<0.1 Gy) and higher (>10 Gy) X-ray doses. We also demonstrate that topographic persistent luminescence dosimetry can record complex clinical dose distributions for dose verification and radiotherapy planning. [Display omitted] ● A new dose verification method based on a stable, reusable, sensitive, and flexible X-ray dosimeter is first reported for clinical radiotherapy. ● This nanoparticle film shows better liner response to irradiation dose compared to commercially available Gafchromic films in the range of 0–25 Gy. ● The film enables accurate X-ray dose measurements for radiotherapy of small tumors in mice and large tumors in rabbits and shows higher signal-to-background ratios. ● The scintillation film can be used to record clinical complex topographic dose patterns and accurately measure the X-ray dose according to patient radiotherapy planning. [ABSTRACT FROM AUTHOR]