Multidisciplinary collaborative consensus guidance statement on the assessment and treatment of neurologic sequelae in patients with post‐acute sequelae of SARS‐CoV‐2 infection (PASC).

This consensus guidance statement reflects input from patient communities and the authors thank the following organizations and individuals for their input during the Collaborative writing process: the Patient-Led Research Collaborative, Angela Meriquez Vazquez, MSW, Long Covid Patient and Advocate, and Lauren Nichols, Long Covid Patient and Chronic Illness Advocate. For example, patients with MS may be on disease modifying therapy (DMT), and both the MS and the DMT may put them at higher risk for COVID-19 acute infections as well as more severe course, though in a recent systematic review these were not consistent findings.<xref ref-type="bibr" rid="bibr58">58</xref> The review included more than 80 reports involving 2493 MS patients and 37 Neuromyelitis Optica Spectrum Disorder patients with COVID-19. Larger number of beds and location in an area with high COVID-19 prevalence were the strongest and most consistent predictors of facilities having more COVID-19 cases and deaths.<xref ref-type="bibr" rid="bibr56">56</xref> This multicenter cohort study showed that delirium was the sixth most common of all presenting symptoms and signs of acute COVID-19 infection, and factors associated with delirium were age older than 75 years, living in a nursing home or assisted living, vision impairment, hearing impairment, stroke, and Parkinson disease.<xref ref-type="bibr" rid="bibr57">57</xref>Though the studies in children are evolving, long COVID is recognized and should be considered at all ages. Patients with GBS/MFS benefit further from intravenous immunoglobulin and plasma exchange.[7] Most patients with isolated cranial neuropathies have a favorable outcome with supportive care compared to patients with multiple cranial neuropathies with GBS, who may achieve partial recovery and experience longer symptom duration. [Extracted from the article]