Baseline Characteristics And Outcomes Among Obese Patients With And Without High Output Heart Failure.

Obesity is the most common etiology of high output heart failure (HOHF). The difference in baseline characteristics and outcomes among obese patients with and without HOHF is not well known. This was a retrospective study including obese patients (BMI >35 kg/m²) from 1/1/2015 to 12/31/2019 at our center. We excluded patients with EF <45%, liver cirrhosis, arteriovenous fistula, heart transplant, and hemodialysis at time of right heart catheterization (baseline). Selected outcomes included all-cause mortality and heart failure readmissions. We included a total of 44 patients with HOHF (cases) and 97 patients without HOHF (controls). Mean age was 62 years in both groups. Majority of patients were females (77% vs 66%; p=0.18) and Caucasians (79% vs 81%; p=0.99) in cases vs controls, respectively. No significant difference in demographics, comorbidities, medications used and labs were noted among two groups (Table 1). The median baseline EF was 60% among both groups. By right heart catheterization, the median Cardiac Index by thermodilution method was 4.0 vs 2.98; p=<0.001 and by Fick method was 4.10 vs 2.96; p=<0.001 at baseline. No significant difference between right atrial (RA), right ventricular, pulmonary artery (PA) and wedge pressures were noted between cases and controls. PA saturation (74.5% vs 72%, p=0.0006) and RA saturation (76% vs 72%, p= <0.0001) were higher among cases. The patients were followed up for median of 31 (IQR=22.3-45.5) months. No significant difference in mortality (13.6% vs 10.3%, p=0.56) among both groups noted. Heart failure readmission rate was higher among cases compared to controls (40.9% vs 11.3%, p=<0.001). (Table 1) Obese patients with HOHF have higher heart failure readmission rate compared to obese patients without HOHF. There is no significant difference in baseline demographics and all-cause mortality among the two groups. [ABSTRACT FROM AUTHOR]