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Mechanism of Learning and Memory Impairment in Rats Exposed to Arsenic and/or Fluoride Based on Microbiome and Metabolome.
- Source :
- Biomedical & Environmental Sciences; Mar2023, Vol. 36 Issue 3, p253-268, 16p
- Publication Year :
- 2023
-
Abstract
- Arsenic (As) and fluoride (F) are two of the most common elements contaminating groundwater resources. A growing number of studies have found that As and F can cause neurotoxicity in infants and children, leading to cognitive, learning, and memory impairments. However, early biomarkers of learning and memory impairment induced by As and/or F remain unclear. In the present study, the mechanisms by which As and/or F cause learning memory impairment are explored at the multi-omics level (microbiome and metabolome). We stablished an SD rats model exposed to arsenic and/or fluoride from intrauterine to adult period. Arsenic and/fluoride exposed groups showed reduced neurobehavioral performance and lesions in the hippocampal CA1 region. 16S rRNA gene sequencing revealed that As and/or F exposure significantly altered the composition and diversity of the gut microbiome, featuring the Lachnospiraceae_NK4A136_group, Ruminococcus_1, Prevotellaceae_NK3B31_group, [Eubacterium]_ xylanophilum_group. Metabolome analysis showed that As and/or F-induced learning and memory impairment may be related to tryptophan, lipoic acid, glutamate, gamma-aminobutyric acidergic (GABAergic) synapse, and arachidonic acid (AA) metabolism. The gut microbiota, metabolites, and learning memory indicators were significantly correlated. Learning memory impairment triggered by As and/or F exposure may be mediated by different gut microbes and their associated metabolites. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08953988
- Volume :
- 36
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Biomedical & Environmental Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 162976376
- Full Text :
- https://doi.org/10.3967/bes2023.028