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GATE/Geant4-based dosimetry for ex vivo in solution irradiation of blood with radionuclides.
- Source :
- Zeitschrift für Medizinische Physik; Feb2023, Vol. 33 Issue 1, p46-53, 8p
- Publication Year :
- 2023
-
Abstract
- To establish a dose-response relationship between radiation-induced DNA damage and the corresponding absorbed doses in blood irradiated with radionuclides in solution under ex vivo conditions, the absorbed dose coefficient for 1 ml for 1 h internal ex vivo irradiation of peripheral blood (d Blood) must be determined. d Blood is specific for each radionuclide, and it depends on the irradiation geometry. Therefore, the aim of this study is to use the Monte Carlo radiation transport code GATE/Geant4 to calculate the mean absorbed dose rates for ex vivo irradiation of blood with several radionuclides used in Nuclear Medicine. The Monte Carlo simulation reproduces the irradiation geometry of a blood sample of 7 ml mixed with 1 ml of a water equivalent radioactive solution in an 8 ml vial. The simulation was performed for ten different radionuclides: <superscript>18</superscript>F, <superscript>68</superscript>Ga, <superscript>90</superscript>Y, <superscript>99m</superscript>Tc, <superscript>123</superscript>I, <superscript>124</superscript>I, <superscript>131</superscript>I, <superscript>177</superscript>Lu, <superscript>223</superscript>Ra, and <superscript>225</superscript>Ac. Two sets of simulations for each radionuclide were performed with 1x10<superscript>9</superscript> histories. The first set was simulated with a mass density of 1.0525 g/cm<superscript>3</superscript> of the blood plus water mixture. The second set of simulations was performed with a mass density of 1 g/cm<superscript>3</superscript> for comparison with previous studies. The values of d Blood for ten radionuclides were calculated. The values range from 10.23 mGy∙ml∙MBq<superscript>−1</superscript> for <superscript>99m</superscript>Tc to 15632.02 mGy∙ml∙MBq<superscript>−1</superscript> for <superscript>225</superscript>Ac. The maximum relative change compared to previous studies was 13.0% for <superscript>124</superscript>I. This study provides a comprehensive set of absorbed dose coefficients for 1 ml for 1 h internal ex vivo irradiation of peripheral blood in a special vial geometry and radionuclides typically used in Nuclear Medicine. Furthermore, the method proposed by this work can be easily adapted to a variety of internal irradiation conditions and serve as a reference for future studies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09393889
- Volume :
- 33
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Zeitschrift für Medizinische Physik
- Publication Type :
- Academic Journal
- Accession number :
- 162593023
- Full Text :
- https://doi.org/10.1016/j.zemedi.2022.03.005