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Antidiabetic potential of Chlorella pyrenoidosa functional formulations in streptozocin-induced type 2 diabetic mice.
- Source :
- Journal of Functional Foods; Apr2023, Vol. 103, pN.PAG-N.PAG, 1p
- Publication Year :
- 2023
-
Abstract
- [Display omitted] • CFF reduces fat accumulation within hepatocytes. • CFF can mediate gut microbiota to regulate disorders of glucose metabolism. • CFF can regulate blood glucose levels through PI3K / AKT / GLUT4, AMPK-α signaling pathways. This study was aimed at investigating the hypoglycemic effect of Chlorella pyrenoidosa functional formulations (CFF), composed of extracts of C. pyrenoudosa , Ganoderma lucidum , and Panax ginseng with chromium-enriched yeast, on streptozotocin (STZ)-induced high-glucose and high-fat diet-fed mice. In this study, CFF significantly reduced the symptoms of weight loss, liver deformation, cecum injury, and jejunal inflammation in type 2 diabetic mice. In addition to enriching gut probiotics, CFF inhibited harmful microorganisms that could affect glycolipid metabolism disorders (GLD) and enhanced production of short-chain fatty acids. In conclusion, CFF may be able to alleviate GLD symptoms. The study suggests that CFF regulates GLD and the possible mechanisms for this regulation. This provides a theoretical basis for developing nutritious and healthy foods. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17564646
- Volume :
- 103
- Database :
- Supplemental Index
- Journal :
- Journal of Functional Foods
- Publication Type :
- Academic Journal
- Accession number :
- 162439558
- Full Text :
- https://doi.org/10.1016/j.jff.2023.105489