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Sumc (Rhus coriaria L.) fruit ameliorates paracetamol-induced hepatotoxicity.
- Source :
- Food Bioscience; Apr2023, Vol. 52, pN.PAG-N.PAG, 1p
- Publication Year :
- 2023
-
Abstract
- Sumac [ Rhus coriaria L. (Anacardiaceae)] is a widely used spice in the Middle East. In this study, the hepatoprotective effects of sumac fruit were evaluated using a rat model of paracetamol-induced liver injury. The experimental design relies on the pretreatment of rats with intraperitoneal sumac extract followed by a toxic dose of paracetamol. Tissue alterations, serum levels of oxidative stress markers, as well as gene expression of immunomarkers were evaluated. Rats pre-treated with sumac displayed attenuated signs of toxicity. Upon paracetamol intoxication, sumac-pretreated animals showed a minimal increase in liver enzyme levels. In parallel, serum albumin and total protein levels were close to normal. Moreover, pretreated sumac animals had preserved hepatocyte morphology, whereas unprotected animals had necrotic deformations. Importantly, these effects were dose-dependent and comparable to the silymarin-treated positive control group. In conclusion, sumac extract offers a potential hepatoprotective regimen against xenobiotic-induced hepatotoxicity and for oxidative stress management. • The hepatoprotective effects of sumac fruit were evaluated. • A rat model of paracetamol-induced liver injury was used. • Rats pre-treated with sumac extract displayed attenuated signs of toxicity. • Serum albumin and total protein levels were near-normal in sumac-treated animals. • Normal hepatocyte morphology was preserved in sumac-pretreated animals. [ABSTRACT FROM AUTHOR]
- Subjects :
- HEPATOTOXICOLOGY
SERUM albumin
FRUIT
OXIDATIVE stress
LIVER enzymes
ANACARDIACEAE
Subjects
Details
- Language :
- English
- ISSN :
- 22124292
- Volume :
- 52
- Database :
- Supplemental Index
- Journal :
- Food Bioscience
- Publication Type :
- Academic Journal
- Accession number :
- 162389730
- Full Text :
- https://doi.org/10.1016/j.fbio.2023.102488