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Design, Synthesis, and Biological Evaluation of Heterocyclic-Fused Pyrimidine Chemotypes Guided by X‑ray Crystal Structure with Potential Antitumor and Anti-multidrug Resistance Efficacy Targeting the Colchicine Binding Site.

Authors :
Tan, Lun
Wu, Chengyong
Zhang, Jifa
Yu, Quanwei
Wang, Xiye
Zhang, Lele
Ge, Meiyi
Wang, Zhijia
Ouyang, Liang
Wang, Yuxi
Source :
Journal of Medicinal Chemistry; 3/9/2023, Vol. 66 Issue 5, p3588-3620, 33p
Publication Year :
2023

Details

Language :
English
ISSN :
00222623
Volume :
66
Issue :
5
Database :
Supplemental Index
Journal :
Journal of Medicinal Chemistry
Publication Type :
Academic Journal
Accession number :
162377556
Full Text :
https://doi.org/10.1021/acs.jmedchem.2c02115