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The results of concentration of care: Surgical outcomes of neuroblastoma in the Netherlands.
- Source :
- European Journal of Surgical Oncology; Feb2023, Vol. 49 Issue 2, p505-511, 7p
- Publication Year :
- 2023
-
Abstract
- Introduction. In the Netherlands pediatric oncological care for solid tumours is concentrated in one centre since November 2014. One of the most frequently diagnosed solid non-brain tumours in children is the neuroblastoma. Results of surgical treatment of neuroblastoma since the start of this centralization are presented and compared to a historic cohort. Methods. The new national cohort of neuroblastoma (n = 111) consists of all consecutive patients treated between January 1st<superscript>,</superscript> 2015 and April 1st<superscript>,</superscript> 2021. The historic neuroblastoma cohort consists of all operated neuroblastoma patients in the Netherlands between 1998 and 2014 (n = 244). Intra-operative complications and surgical outcome were registered. Post-operative complications were divided in short (<30 days after surgery) and long term (>30 days). The severity of complications was graded using the Clavien Dindo Classification (CDC) system. Results. Intraoperative outcomes showed significant differences in favour of the new cohort with less blood loss (p < 0.001), fewer vascular complications (p < 0.001) and shorter duration of surgery (p < 0.001). Short term complications were comparable in numbers, but significantly more patients had CDC grade 3/4/5 complications in the historic cohort (p = 0.005). Long term complications did not differ. Estimated overall survival showed a better survival in the new cohort (log rank 0.022). Conclusion. Centralization of care for neuroblastoma patients has led to a significant improvement of both intraoperative outcomes and short term complications. [ABSTRACT FROM AUTHOR]
- Subjects :
- NEUROBLASTOMA
SURGICAL complications
PEDIATRIC therapy
OVERALL survival
Subjects
Details
- Language :
- English
- ISSN :
- 07487983
- Volume :
- 49
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- European Journal of Surgical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 162010868
- Full Text :
- https://doi.org/10.1016/j.ejso.2022.10.005