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Effect of chronic exposure to ketohexoses on pancreatic β-cell function in INS-1 rat insulinoma cells.
- Source :
- Bioscience, Biotechnology & Biochemistry; Feb2023, Vol. 87 Issue 2, p163-170, 8p
- Publication Year :
- 2023
-
Abstract
- Glucotoxicity, impaired insulin secretion, suppression of insulin gene expression, and apoptosis, in pancreatic β-cells caused by chronic hyperglycemia is a key component of the pathogenesis of type 2 diabetes. Recently, it has been reported that rare sugar D-allulose has antihyperglycemic and antihyperlipidemic effects in diabetic rats. However, the direct effects of rare sugars including D-allulose on pancreatic β-cell function are unclear. In this study, we investigated whether chronic exposure to ketohexoses causes glucotoxicity, suppression of insulin gene expression, and apoptosis, in INS-1 rat pancreatic insulinoma cells. D-Fructose, D-tagatose, L-allulose, and L-sorbose treatment for 1-week reduced insulin gene expression, whereas D-allulose, D-sorbose, L-fructose, and L-tagatose did not. All ketohexoses were transported into INS-1 cells, but were not metabolized. In addition, the ketohexoses did not induce apoptosis and did not affect glucose metabolism. These results suggest that long-term administration of D-allulose, D-sorbose, L-fructose, and L-tagatose does not affect pancreatic β-cell function. [ABSTRACT FROM AUTHOR]
- Subjects :
- HYPERGLYCEMIA
INSULINOMA
TYPE 2 diabetes
GENE silencing
GENE expression
RATS
Subjects
Details
- Language :
- English
- ISSN :
- 09168451
- Volume :
- 87
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Bioscience, Biotechnology & Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 161613175
- Full Text :
- https://doi.org/10.1093/bbb/zbac190