Denoising Autoencoder based Long non-coding RNA-Disease Association Prediction.

Long non-coding RNAs (lncRNAs) are recent listing in RNA Bioinformatics, which is getting more popular due to their important functional roles. According to the available research, lncRNAs play an essential role in multiple complex diseases. Determining the function of lncRNAs in diseases will help to comprehend many missing links in the disease mechanism. Predicting lncRNAdisease association (LDA) is a crucial stage in this process which is getting at most research interest nowadays. The developments in machine learning and deep learning technologies influenced recent research on LDA models. Most of the methods analyse the interactions of lncRNA with other molecules such as microRNA (miRNA), messenger RNA(mRNA), and proteins. Deep learning models, specifically from autoencoder classes, used extensively in unsupervised learning of features from these associations. This research paper proposes a denoising autoencoder (DAE) based LDA prediction approach. The proposed model uses DAE to learn lncRNA-disease representations from multiple biological networks such as lncRNA-miRNA, miRNA-disease, and disease-lncRNA interactions. The experiments show that the model outperforms other state-of-the-art LDA models concerning the area under the ROC curve (AUC-ROC, 0.94) and the area under precision-recall (AUPR, 0.9592). [ABSTRACT FROM AUTHOR]