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Ex vivo perfusion of the human placenta to investigate pregnancy pathologies.
- Source :
- Placenta; Dec2022, Vol. 130, p1-8, 8p
- Publication Year :
- 2022
-
Abstract
- Pregnancy pathologies including gestational diabetes, intrauterine fetal growth restriction, and pre-eclampsia are common and significantly increase the risk of poor pregnancy outcomes. Research to better understand the pathophysiology and improve diagnosis and treatment is therefore crucial. The ex vivo placenta perfusion model offers a unique system to study pregnancy pathology without the risk of harm to mother or fetus. The presence of a maternal and fetal circulation and intact villus tree, facilitates investigations into maternal-fetal transfer, altered hemodynamics and vascular reactivity in the human placenta. It also provides a platform to test novel therapeutic agents. Here we review the key studies which have utilized the ex vivo placenta perfusion model to study different aspects of such pregnancy pathologies. [ABSTRACT FROM AUTHOR]
- Subjects :
- PLACENTA
FETAL growth retardation
QUESTIONNAIRES
PREECLAMPSIA
PERFUSION
Subjects
Details
- Language :
- English
- ISSN :
- 01434004
- Volume :
- 130
- Database :
- Supplemental Index
- Journal :
- Placenta
- Publication Type :
- Academic Journal
- Accession number :
- 160506528
- Full Text :
- https://doi.org/10.1016/j.placenta.2022.10.006