Synthesis and anti-hepatocellular carcinoma effects of corydamine from Hypecoum Leptocarpum.

Hypecoum leptocarpum is a traditional Tibetan Medicine, which has been shown to have anti-cancer properties. Therefore, developing anti-cancer activity compounds from Hypecoum leptocarpum is very valuable. Notably, corydamine, an isoquinoline alkaloid, is isolated from Hypecoum leptocarpum. Given the anti-cancer value of Hypecoum leptocarpum , lucubrating the anti-cancer activity of corydamine is of great value in the development of novel anti-cancer drugs. In this study, synthesis and anti-cancer activity evaluation of corydamine were completed. The research in vitro confirmed corydamine suppressed cell proliferation and metastasis, arrested cell cycle at G 1 /G 0 phase, triggered mitochondrial pathway apoptosis through inhibiting the activation of PI3K/AKT/mTOR pathway. Studies in vivo on LM9 xenograft nude mice demonstrated that corydamine therapy markedly inhibited tumor growth. These findings revealed corydamine might be a candidate for the treatment of hepatocellular carcinoma. [Display omitted] • Corydamine exerted significant anti-proliferation effect on hepatic carcinoma cells. • Corydamine treatment markedly inhibited tumor growth on LM9 xenograft nude mice. • Corydamine inhibited the activation of PI3K/Akt/mTOR signaling pathway. [ABSTRACT FROM AUTHOR]