Aminoglycosides correct the phenotype of ataxiatelangiectsia cells.

Cites a study conducted by researchers in the U.S., which found that approximately 14 percent of genetic mutations in patients with ataxiatelangiectsia are single-nucleotide changes that results in primary premature termination codons. Purpose of the study regarding the correction of phenotype of ataxiatelangiectsia cells; Uses of radiosensitivity, radioresistant DNA synthesis and irradiation-induced autophosphorylation of ATM (A-T mutated) Ser-1981 to show that the aminoglycoside-induced full-length ATM protein was functional and corrected.